Learn About

Go To--> Learn About | Health | Neurological Disorders | Alzheimer's and Dementia

Article: Fact Sheet - Dementia with Lewy Bodies

Dementia with Lewy Bodies

Table of Contents

1. Dementia with Lewy Bodies

Definition

Dementia with Lewy bodies (DLB) is a progressive degenerative disease or syndrome of the brain. It shares symptoms, and sometimes overlaps, with several diseases, especially Alzheimerʼs and Parkinsonʼs.

People who develop DLB have behavioral and memory symptoms of dementia similar to those of Alzheimerʼs disease and, to varying extents, to the physical and motor system symptoms seen in Parkinsonʼs disease. However, there are some distinct contrasts to these conditions. The mental symptoms of a person with DLB might fluctuate frequently, motor symptoms are milder than for Parkinsonʼs, and DLB patients usually have vivid visual hallucinations.

Facts

Dementia with Lewy bodies (DLB) is also called “Lewy body dementia” (LBD), “diffuse Lewy body disease,” “Lewy body disease,” “cortical Lewy body disease,” “Lewy body variant of Alzheimer's disease” or “Parkinson's disease dementia.” It is the second most common dementia, accounting for 20% of those with dementia (Alzheimerʼs disease is first). Dementia is a gradual, progressive decline in mental ability (cognition) that affects memory, thinking processes, behavior, and physical activity. In addition to these mental symptoms, persons with DLB experience physical symptoms of parkinsonism, including mild tremor, muscle stiffness, and movement problems. Strong visual hallucinations also occur.

DLB is named after smooth round protein lumps (alpha-synuclein) called Lewy bodies that are found in the nerve cells of the affected parts of the brain. These “abnormal protein structures” were first described in 1912 by Frederich Heinrich Lewy, M.D., a contemporary of Alois Alzheimer who first identified the more common form of dementia that bears his name.

Lewy bodies are found throughout the outer layer of the brain (the cerebral cortex) and deep inside the midbrain and brainstem. They are often found in those diagnosed with Alzheimerʼs, Parkinsonʼs, Down syndrome, and other disorders.

The cause of DLB is unknown, and no specific risk factors are identified. Cases have appeared among families, but there does not seem to be a strong tendency for inheriting the disease. Genetic research may reveal more information about causes and risk in the future. It usually occurs in older adults between 50–85 years old, and slightly more men than women have the disease.

Symptoms

Initial symptoms of DLB usually are similar to those of Alzheimerʼs or vascular dementia and are cognitive in nature, such as acute confusion, loss of memory, and poor judgment. Other patients may first show the neuromuscular symptoms of parkinsonism—loss of spontaneous movement, rigidity (muscles feel stiff and resist movement), and shuffling gait, while still others may have visual hallucinations as the first symptom. Patients may also suffer from delusions or depression.

Key symptoms are:

• Problems with recent memory such as forgetting recent events.
• Brief episodes of unexplained confusion and other behavioral or cognitive problems. The individual may become disoriented to the time or location where he or she is, have trouble with speech, have difficulty finding words or following a conversation, experience visuospatial difficulty (for example, finding oneʼs way), and have problems in thinking such as inattention, mental inflexibility, indecisiveness, lack of judgment, lack of initiative, and loss of insight.
• Fluctuation in the occurrence of cognitive symptoms from moment to moment, hour to hour, day to day, or week to week. For example, the person may converse normally one day and be mute and unable to speak the next day. There are also fluctuations in attention, alertness, and wakefulness.
• Well-defined, vivid, recurrent visual hallucinations. These hallucinations are well formed and detailed. In DLBʼs early stage, the person may even acknowledge and describe the hallucinations. They are generally benign and patients are not scared by them. Hallucinations may also be auditory (hearing sounds), olfactory (smelling or tasting something), or tactile (feeling or touching something that is not there).
• Movement problems of parkinsonism, sometimes referred to as “extrapyramidal” signs. These symptoms often seem to start spontaneously and may include flexed posture, shuffling gait, muscle jerks or twitches, reduced arm swing, loss of dexterity, limb stiffness, a tendency to fall, balance problems, bradykinesia (slowness of movement), tremor, shakiness, and lack of facial expression.
• Rapid eye movement sleep behavior disorder. This is characterized by vivid dreaming, talking in oneʼs sleep, and excessive movement while asleep, including occasionally hitting a bed partner. The result may be excessive daytime drowsiness, and this symptom may appear years before DLB is diagnosed. About 50% of patients have this symptom.

Movement and motor problems occur in later stages for 70% of persons with DLB. But for 30% of DLB patients, and more commonly those that are older, Parkinsonʼs symptoms occur first, before dementia symptoms. In these individuals, cognitive decline tends to start with depression or mild forgetfulness.

Testing and Diagnosis

Dementia with Lewy bodies is difficult to diagnose. Not only does it resemble other dementias, it overlaps with Alzheimerʼs, Parkinsonʼs and other disorders, which may result in it being difficult to rule out or exclude. Because no single test exists to diagnose DLB, a variety of medical, neurological and neuropsychological tests are used to pinpoint it and its possible overlap with other illnesses. A definitive diagnosis can be made only by an autopsy at death. There are no medications currently approved to specifically treat DLB.

Although Lewy bodies are found in brains of patients with other diseases, and because testing will involve several approaches, it is useful to understand what happens to the brain of a person with DLB. Three significant changes or pathological features are seen in brains afflicted by DLB:

• The brainʼs cerebral cortex (outer layers of the brain) degenerates or shrinks. This can affect reasoning and complex thinking, understanding personality, movement, speech and language, sensory input, and visual perceptions of space. Degeneration also occurs in the limbic cortex at the center of the brain, which plays a major role in emotions and behavior. Lewy bodies form throughout these degenerating cortical areas.
• Nerve cells die in the midbrain, especially in an area that also degenerates in Parkinsonʼs disease, the substantia nigra, located in the brainstem. These cells are involved in making the neurotransmitter (brain messenger) dopamine. Lewy bodies are found in the nerve cells that remain. The midbrain is involved in memory formation and learning, attention, and psychomotor (muscular movement) skills.
• Lesions called Lewy neuritis that affect nerve cell function are found in DLB brains, especially in the hippocampus, an area of the brain essential for forming new memories.

None of the symptoms of dementia with Lewy bodies is specific only to DLB. To address this problem, an international group of researchers and clinicians developed a set of diagnostic criteria in 1995, called the Consensus Guidelines that can reliably point to DLB:

Must be present:

• Progressive cognitive decline (decrease in thinking ability) that interferes with normal social or occupational activities. Memory problems do not necessarily occur in the early period but will occur as DLB progresses. Attention, language, understanding and reasoning, ability to do arithmetic, logical thinking, and perceptions of space and time will be impaired.

Two of the following are present (one also indicates possibility of DLB):

• Fluctuating cognition and mental problems, vary during the day, especially attention and alertness.
• Visual hallucinations, detailed and well-formed visions occur and recur.
• Parkinsonism: motor-related and movement problems appear.

A DLB diagnosis is even more likely if the patient also experiences repeated falls, fainting, brief loss of consciousness, delusions, or is sensitive to neuroleptic medications that are given to control hallucinations and other psychiatric symptoms.

Finally, the timing of symptoms is a reliable clue: if both mental and motor symptoms appear within one year of each other, DLB is more likely the cause. Signs of stroke or vascular dementia usually negate the likelihood of DLB.

Testing is usually done to rule out other possible causes of dementia. Brain imaging (CT scan or MR imaging) can detect brain shrinkage and help rule out stroke, fluid on the brain (normal pressure hydrocephalus), or subdural hematoma. Blood and other tests might show vitamin B12 deficiency, thyroid problems, syphilis, HIV, or vascular disease. Depression is also a common cause of dementia-like symptoms. Additional tests can include an electroencephalogram (EEG) or spinal tap. Scans using SPECT or PET technology have shown promise in detecting differences between DLB and Alzheimer's disease.

Alzheimer’s and Parkinson’s: Differences and Overlap with DLB

DLBʼs similarity to Alzheimerʼs and Parkinsonʼs diseases and the fact that Lewy bodies are often found in the brains of patients with these diseases means that clinicians must pay close attention to the factors that distinguish DLB:

• Memory and other cognitive problems occur in both DLB and Alzheimerʼs. However, in DLB they fluctuate frequently.
• DLB patients experience more depression than do Alzheimerʼs patients.
• Hallucinations are experienced by Alzheimerʼs patients in late stages, and by Parkinsonʼs patients who take medications to improve movement and tremor. In DLB, hallucinations occur in early stages, and they are frequent, vivid, and detailed.
• Neuroleptic drugs (sometimes called psychotropic drugs) prescribed to lessen the so-called psychiatric symptoms of dementia, such as hallucinations, agitation, or restlessness will induce Parkinsonʼs in some DLB patients.
• Life expectancy is slightly shorter for DLB than for Alzheimerʼs patients.
• At autopsy the brains of DLB patients have senile plaques, a hallmark of Alzheimerʼs. Another Alzheimerʼs feature, neurofibrillary tangles, are absent or found in fewer numbers and are concentrated in the neocortex. Other Alzheimerʼs features—regional neuronal loss, spongiform change and synapse loss, neurochemical abnormalities and neurotransmitter deficits—are also seen. However, DLB-afflicted brains are less damaged than are Alzheimerʼs brains.
• In DLB, movement problems are spontaneous; the symptoms begin suddenly.
• Tremor is less pronounced in DLB than in Parkinsonʼs. Also, DLB patients respond less dramatically to drugs such as Levodopa that are used to treat Parkinsonʼs. Nerve cell loss in the subtantia nigra is not as severe in DLB. Both DLB and Parkinsonʼs patients may sometimes experience fainting and wide alterations in blood pressure. Some Parkinsonʼs patients develop dementia in later stages. Dementia is usually the presenting symptom in DLB.
• Parkinsonʼs patients lose the neurotransmitter dopamine; Alzheimerʼs patients lose the neurotransmitter acetylcholine. DLB patients lose both.
• In DLB, Alzheimer-like and Parkinson-like symptoms appear within one year of each other.

Despite these differences, a diagnosis of dementia with Lewy bodies does not preclude a positive diagnosis of Alzheimerʼs, Parkinsonʼs, or other diseases common in older age.

Duration and Treatment

With an average lifespan after onset of 5 to 7 years, the progress of dementia with Lewy bodies is relentless; however, the rate of decline varies with each person. DLB does not follow a pattern of stages as is seen in some other dementias. Death usually occurs from pneumonia or other illness. There is neither cure nor specific treatment to arrest the course of the disease.

Caution must be used in treating a person with DLB. Medications must be monitored closely for proper balance because some patients are adversely affected by some drugs. Neuroleptic (tranquilizing) anti-psychotic medications such as haloperidol (Haldol) or thioridazine (Mellaril), as well as benzodiazepines (Valium, Ativan) and antihistamines can cause extreme adverse reactions in DLB patients. Side effects include motor-related symptoms, catatonia (non-responsiveness), loss of cognitive function, and/or development of muscle rigidity. These medications are sometimes used in Alzheimerʼs patients to help with hallucinations and behavioral symptoms, but should not be used in patients with DLB. Levodopa may be given to treat the parkinsonism, however, it may increase the hallucinations of DLB patients and aggravate other symptoms, such as cognitive functioning. It is less effective in treating tremor in DLB patients than in Parkinsonʼs patients. Aricept or other cholinesterase inhibitors are given to treat the hallucinations. Some antidepressants have shown positive results, while others are counterindicated.

When considering surgery, families should meet with the anesthesiologist to discuss possible side effects of anesthesia, as DLB patients are prone to delusions and a decline in motor functioning after anesthesia.

Caregiving and DLB

DLB patients can live at home with frequent reassessment and careful monitoring and supervision. Caregivers must watch the patient closely because of the tendency for them to fall or lose consciousness. Particular care should be taken when a patient is standing up from a chair or getting out of bed, as blood pressure can drop, causing the patient to lose his or her balance. Dementia prevents patients from learning new actions that might help them overcome movement problems, such as learning to use a walker. They may need more assistance some days than others, and can be reassured by a caregiver's help in turning attention away from the hallucinations.

Caregivers must learn to navigate both skills in dealing with cognitive, behavioral, and motor disabilities. Attending support groups and learning skills in how to communicate with someone with dementia, as well as learning skills in helping someone with a motor disorder, will reduce caregiver stress and frustration.

Caregivers can turn to a California Caregiver Resource Center for assistance and to a qualified diagnostic center for initial diagnosis and follow up. In other states, resources can be found through local and state offices on aging and health such as your Area Agency on Aging or the Alzheimerʼs Association in your area.

Resources

Family Caregiver Alliance
National Center on Caregiving
(415) 434-3388 | (800) 445-8106
Website: www.caregiver.org
Email: [email protected] (link sends e-mail)
FCA CareJourney: www.caregiver.org/carejourney
Family Care Navigator: www.caregiver.org/family-care-navigator

Family Caregiver Alliance (FCA) seeks to improve the quality of life for caregivers through education, services, research and advocacy. Through its National Center on Caregiving, FCA offers information on current social, public policy, and caregiving issues, provides assistance in the development of public and private programs for caregivers, publishes timely reports, newsletters, and fact sheets, and assists caregivers nationwide in locating resources in their communities. For San Francisco Bay Area residents, FCA provides direct family support services for caregivers of those with Alzheimer's disease, stroke, ALS, head injury, Parkinson's, and other debilitating health conditions that strike adults.

Other Organizations and Links

Lewy Body Dementia Association
www.lbda.org (link is external)

LewyNet, The University of Nottingham, Nottingham, England
www.nottingham.ac.uk/pathology/lewy/lewyinfo.html (link is external)

This fact sheet was prepared by Family Caregiver Alliance and reviewed by William Jagust, MD . © 2001, 2010, 2018  Family Caregiver Alliance. All rights reserved.

Last Updated on 1/29/2018